Transforming XML file: NeuroMLFiles/Examples/ChannelML/GateDepQ10.xml using XSL file: NeuroMLFiles/Schemata/v1.8.1/Level2/ChannelML_v1.8.1_NEURONmod.xsl

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Converting the file: GateDepQ10.xml


? This is a NEURON mod file generated from a ChannelML file

? Unit system of original ChannelML file: Physiological Units

COMMENT
    ChannelML file containing a single Channel description
ENDCOMMENT

TITLE Channel: NaConduction

COMMENT
    Example showing a channel with different Q10 adjustments for each gate, based on HH Na example
ENDCOMMENT


UNITS {
    (mA) = (milliamp)
    (mV) = (millivolt)
    (S) = (siemens)
    (um) = (micrometer)
    (molar) = (1/liter)
    (mM) = (millimolar)
    (l) = (liter)
}


    
NEURON {
  
    SUFFIX NaConduction
    USEION na READ ena WRITE ina VALENCE 1 ? reversal potential of ion is read, outgoing current is written
           
        
    RANGE gmax, gion
    
    RANGE minf, mtau
    
    RANGE hinf, htau
    
}

PARAMETER {
  
    gmax = 0.12 (S/cm2) ? default value, should be overwritten when conductance placed on cell
    
}



ASSIGNED {
  
    v (mV)
    
    celsius (degC)
      
    ? Reversal potential of na
    ena (mV)
    ? The outward flow of ion: na calculated by rate equations...
    ina (mA/cm2)
    
    
    gion (S/cm2)
    minf
    mtau (ms)
    hinf
    htau (ms)
    
}

BREAKPOINT {
                        
    SOLVE states METHOD cnexp
        
    gion = gmax * ((1*m)^3) * ((1*h)^1)
    ina = gion*(v - ena)
            

}



INITIAL {
    
    ena = 50
        
    rates(v)
    m = minf
        h = hinf
        
    
}
    
STATE {
    m
    h
    
}



DERIVATIVE states {
    rates(v)
    m' = (minf - m)/mtau
            h' = (hinf - h)/htau
            

}

PROCEDURE rates(v(mV)) {
    
    ? Note: not all of these may be used, depending on the form of rate equations
    LOCAL alpha, beta, tau, inf, gamma, zeta, temp_adj_m,
         A_alpha_m, B_alpha_m, Vhalf_alpha_m,
         A_beta_m, B_beta_m, Vhalf_beta_m, temp_adj_h,
         A_alpha_h, B_alpha_h, Vhalf_alpha_h,
         A_beta_h, B_beta_h, Vhalf_beta_h
    TABLE minf, mtau,hinf, htau DEPEND celsius FROM -100 TO 100 WITH 400
    
    UNITSOFF
    
    ? There is a Q10 factor which will alter the tau of the gates
            
    temp_adj_m = 3^((celsius - 17)/10)
                        
    temp_adj_h = 3.5^((celsius - 17)/10)
                        
            
                
       
        
    ? *** Adding rate equations for gate: m ***
        
    ? Found a parameterised form of rate equation for alpha, using expression: A*((v-Vhalf)/B) / (1 - exp(-((v-Vhalf)/B)))
    A_alpha_m = 1
    B_alpha_m = 10
    Vhalf_alpha_m = -40
    alpha = A_alpha_m * vtrap((v - Vhalf_alpha_m), B_alpha_m)
    
    
    ? Found a parameterised form of rate equation for beta, using expression: A*exp((v-Vhalf)/B)
    A_beta_m = 4
    B_beta_m = -18
    Vhalf_beta_m = -65
    beta = A_beta_m * exp((v - Vhalf_beta_m) / B_beta_m)
    
    mtau = 1/(temp_adj_m*(alpha + beta))
    minf = alpha/(alpha + beta)
    


    ? *** Finished rate equations for gate: m ***
    

    
            
                
       
        
    ? *** Adding rate equations for gate: h ***
        
    ? Found a parameterised form of rate equation for alpha, using expression: A*exp((v-Vhalf)/B)
    A_alpha_h = 0.07
    B_alpha_h = -20
    Vhalf_alpha_h = -65
    alpha = A_alpha_h * exp((v - Vhalf_alpha_h) / B_alpha_h)
    
    
    ? Found a parameterised form of rate equation for beta, using expression: A / (1 + exp((v-Vhalf)/B))
    A_beta_h = 1
    B_beta_h = -10
    Vhalf_beta_h = -35
    beta = A_beta_h / (exp((v - Vhalf_beta_h) / B_beta_h) + 1)
    
    htau = 1/(temp_adj_h*(alpha + beta))
    hinf = alpha/(alpha + beta)
    


    ? *** Finished rate equations for gate: h ***
    

     
}


? Function to assist with parameterised expressions of type linoid/exp_linear

FUNCTION vtrap(VminV0, B) {
    if (fabs(VminV0/B) < 1e-6) {
    vtrap = (1 + VminV0/B/2)
}else{
    vtrap = (VminV0 / B) /(1 - exp((-1 *VminV0)/B))
    }
}

UNITSON

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